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Targeted Allele Detail
Symbol: Mostm1Ev
Name: Moloney sarcoma oncogene; targeted mutation 1, Martin L Evans
MGI ID: MGI:1857218
Synonyms: mos-
Gene: Mos  Location: Chr4:3870658-3872105 bp, - strand  Genetic Position: Chr4, 2.16 cM, cytoband A1-A2
Germline Transmission:  Earliest citation of germline transmission: J:19118
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into the middle of the single coding exon of the gene, introducing an amber stop codon into the reading frame and terminating translation upstream of sequences essential for kinase activity. (J:19118)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Mos Mutation:  13 strains or lines available
Original:  J:19118 Colledge WH, et al., Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs [see comments]. Nature. 1994 Jul 7;370(6484):65-8
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory