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Magtm1Rod
Targeted Allele Detail
Nomenclature
Symbol: Magtm1Rod
Name: myelin-associated glycoprotein; targeted mutation 1, John Roder
MGI ID: MGI:1857216
Gene: Mag  Location: Chr7:30899176-30914873 bp, - strand  Genetic Position: Chr7, 19.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:18407
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 5 of the gene. Mutant mice showed a complete lack of mRNA and protein in the central nervous system for the targeted gene. Nerves from the peripheral nervous system also lacked protein for the targeted gene. (J:18407)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mag Mutation:  17 strains or lines available
References
Original:  J:18407 Li C, et al., Myelination in the absence of myelin-associated glycoprotein. Nature. 1994 Jun 30;369(6483):747-50
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory