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Targeted Allele Detail
Symbol: Lrpap1tm1Her
Name: low density lipoprotein receptor-related protein associated protein 1; targeted mutation 1, Joachim Herz
MGI ID: MGI:1857214
Synonyms: RAP-
Gene: Lrpap1  Location: Chr5:35091490-35105766 bp, - strand  Genetic Position: Chr5, 18.01 cM
Germline Transmission:  Earliest citation of germline transmission: J:43736
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into sequences that encode the leader peptide. Immunoblot analysis of liver and brain did not detect the encoded protein in homozygous animals. (J:43736)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Lrpap1 Mutation:  3 strains or lines available
ES cell line = JH1 or AB1 (129S7/SvEvBrd-Hprt+).

Original:  J:43736 Willnow TE, et al., Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4537-41
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory