Lck^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Lck^tm1Mak
• Name: lymphocyte protein tyrosine kinase; targeted mutation 1, Tak Mak
• MGI ID: MGI:1857211
• Synonyms: lck-, Lck-deficient, lck^null, p56^lck
• Gene: Lck Location: Chr4:129442142-129467415 bp, - strand Genetic Position: Chr4, 63.26 cM, cytoband distal
• Alliance: Lck^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:1119
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 12 of the gene. Western blots of lysates from thymus or lymph nodes showed no detectable protein from the targeted gene. (J:1119)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Lck^tm1Mak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lck Mutation: 93 strains or lines available

References

• Original: J:1119 Molina TJ, et al., Profound block in thymocyte development in mice lacking p56lck [see comments]. Nature. 1992 May 14;357(6374):161-4
• All: 74 reference(s)