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Itga5tm1Hyn
Targeted Allele Detail
Nomenclature
Symbol: Itga5tm1Hyn
Name: integrin alpha 5 (fibronectin receptor alpha); targeted mutation 1, Richard Hynes
MGI ID: MGI:1857207
Synonyms: alpha5-, alpha5-null
Gene: Itga5  Location: Chr15:103344286-103366763 bp, - strand  Genetic Position: Chr15, 58.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:16248
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced 330 bp of the gene, deleting most of the first exon. (J:16248)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 49 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itga5 Mutation:  34 strains or lines available
References
Original:  J:16248 Yang JT, et al., Embryonic mesodermal defects in alpha 5 integrin-deficient mice. Development. 1993 Dec;119(4):1093-105
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory