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Itga4tm1Hyn
Targeted Allele Detail
Nomenclature
Symbol: Itga4tm1Hyn
Name: integrin alpha 4; targeted mutation 1, Richard Hynes
MGI ID: MGI:1857206
Synonyms: alpha4KO, alpha4-null
Gene: Itga4  Location: Chr2:79255426-79333114 bp, + strand  Genetic Position: Chr2, 47.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23140
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 950 bp fragment which contained most of the first exon of the gene. (J:23140)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itga4 Mutation:  39 strains or lines available
References
Original:  J:23140 Yang JT, et al., Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development. 1995 Feb;121(2):549-60
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory