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Targeted Allele Detail
Symbol: Insrtm1Dac
Name: insulin receptor; targeted mutation 1, Domenico Accili
MGI ID: MGI:1857204
Synonyms: Insr-, IR-, IRKO, L1
Gene: Insr  Location: Chr8:3200922-3329649 bp, - strand  Genetic Position: Chr8, 1.82 cM
Alliance: Insrtm1Dac page
Germline Transmission:  Earliest citation of germline transmission: J:33408
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA premature chain termination was introduced downstream from codon 306 of exon 4 of the gene. Western blots of brain extracts from homozygous mutant mice showed no detectable insulin receptor protein. Reverse transcriptase-PCR of RNA isolated from brain, liver and skeletal muscle showed no transcript. (J:33408)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Insr Mutation:  69 strains or lines available
Original:  J:33408 Accili D, et al., Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet. 1996 Jan;12(1):106-9
All:  54 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory