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Inhbbtm1Jae
Targeted Allele Detail
Nomenclature
Symbol: Inhbbtm1Jae
Name: inhibin beta-B; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:1857203
Synonyms: bb1, bb2, Inhbb-
Gene: Inhbb  Location: Chr1:119415465-119422248 bp, - strand  Genetic Position: Chr1, 52.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:16995
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 1.3 kb region of the gene, which spanned the translational start codon, the signal peptide coding region, and most of exon 1 of the gene. In the construct designated bb1, the neomycin cassette was inserted in the same transcriptional orientation as the gene; in the construct designated bb2, the neomycin cassette was inserted in the reverse orientation. (J:16995)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Inhbb Mutation:  17 strains or lines available
References
Original:  J:16995 Vassalli A, et al., Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev. 1994 Feb 15;8(4):414-27
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory