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Il6tm1Kopf
Targeted Allele Detail
Nomenclature
Symbol: Il6tm1Kopf
Name: interleukin 6; targeted mutation 1, Manfred Kopf
MGI ID: MGI:1857197
Synonyms: Il6-, IL-6-, IL-6 KO, Il6tm1Koe, Il6tm1Kopf
Gene: Il6  Location: Chr5:30013114-30019975 bp, + strand  Genetic Position: Chr5, 15.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17360
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 2. RT-PCR experiments on RNA derived from LPS-stimulated macrophages of homozygous mice demonstrated that no detectable transcript was produced from this allele. ELISA and bioassay experiments confirmed that no functional protein was made in homozygous mice. (J:17360)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 9 strains available      Cell Lines: 0 lines available
Carrying any Il6 Mutation:  25 strains or lines available
References
Original:  J:17360 Kopf M, et al., Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature. 1994 Mar 24;368(6469):339-42
All:  544 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory