Il4^tm2Nnt
Targeted Allele Detail

Summary

• Symbol: Il4^tm2Nnt
• Name: interleukin 4; targeted mutation 2, Nancy Noben-Trauth
• MGI ID: MGI:1857195
• Synonyms: IL-4-
• Gene: Il4 Location: Chr11:53503287-53509492 bp, - strand Genetic Position: Chr11, 31.97 cM
• Alliance: Il4^tm2Nnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36386
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance cassette was inserted into exon 3 of the gene. (J:36386)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Il4 Mutation: 42 strains or lines available

Notes

Susceptibility to Leishmania major in BALB/c mice has been ablated by introduction of a null mutant of the Il4 gene (J:35236), but in that study the introduced mutant came from a strain 129 background, and 129 is resistant to L. major infection. In mice carrying one of Noben-Trauth's null mutants, targeted in BALB/c embryonic stem cells, the loss of Il4 expression did not remove susceptibility to infection (J:31486).

References

• Original: J:36386 Noben-Trauth N, et al., Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line. Transgenic Res. 1996 Nov;5(6):487-91
• All: 97 reference(s)