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Il4tm2Nnt
Targeted Allele Detail
Nomenclature
Symbol: Il4tm2Nnt
Name: interleukin 4; targeted mutation 2, Nancy Noben-Trauth
MGI ID: MGI:1857195
Synonyms: IL-4-
Gene: Il4  Location: Chr11:53612460-53618665 bp, - strand  Genetic Position: Chr11, 31.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36386
Parent Cell Line:  BALB/c-I (ES Cell)
Strain of Origin:  BALB/cJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A neomycin resistance cassette was inserted into exon 3 of the gene. (J:36386)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Il4 Mutation:  30 strains or lines available
Notes
Susceptibility to Leishmania major in BALB/c mice has been ablated by introduction of a null mutant of the Il4 gene (J:35236), but in that study the introduced mutant came from a strain 129 background, and 129 is resistant to L. major infection. In mice carrying one of Noben-Trauth's null mutants, targeted in BALB/c embryonic stem cells, the loss of Il4 expression did not remove susceptibility to infection (J:31486).
References
Original:  J:36386 Noben-Trauth N, et al., Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line. Transgenic Res. 1996 Nov;5(6):487-91
All:  93 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory