Il4^tm1Cgn
Targeted Allele Detail

Summary

• Symbol: Il4^tm1Cgn
• Name: interleukin 4; targeted mutation 1, University of Cologne
• MGI ID: MGI:1857194
• Synonyms: IL-4-, IL4^-, IL-4KO, IL-4 KO, IL4T, IL-4T^-, IL4^tm1cgn129
• Gene: Il4 Location: Chr11:53503287-53509492 bp, - strand Genetic Position: Chr11, 31.97 cM
• Alliance: Il4^tm1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:704
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A translational stop codon and a neomycin resistance gene were inserted into the first exon of the gene. (J:704)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Il4 Mutation: 42 strains or lines available

References

• Original: J:704 Kuhn R, et al., Generation and analysis of interleukin-4 deficient mice. Science. 1991 Nov 1;254(5032):707-10
• All: 211 reference(s)