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Il2tm1Hor
Targeted Allele Detail
Nomenclature
Symbol: Il2tm1Hor
Name: interleukin 2; targeted mutation 1, Ivan Horak
MGI ID: MGI:1857191
Synonyms: Il2-, IL-2-, IL-2 KO, IL-2null
Gene: Il2  Location: Chr3:37120523-37125959 bp, - strand  Genetic Position: Chr3, 18.3 cM, cytoband B-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39989
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Il2 Mutation:  16 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:15223). Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:51450) with B2m.

References
Original:  J:39989 Schorle H, et al., Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature. 1991 Aug 15;352(6336):621-4
All:  169 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory