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Igkctm1Cgn
Targeted Allele Detail
Nomenclature
Symbol: Igkctm1Cgn
Name: immunoglobulin kappa constant; targeted mutation 1, University of Cologne
MGI ID: MGI:1857188
Synonyms: CkappaT, kappa-
Gene: Igkc  Location: Chr6:70703419-70703738 bp, + strand  Genetic Position: Chr6, 32.04 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64287
Parent Cell Line:  BL/6-III (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the exon encoding the constant region of the immunoglobulin kappa chain, its splicing signal and polyadenylation site. (J:64287, J:261505)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Igkc Mutation:  6 strains or lines available
References
Original:  J:64287 Zou YR, et al., Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa. EMBO J. 1993 Mar;12(3):811-20
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory