Htt^tm1Mem
Targeted Allele Detail

Summary

• Symbol: Htt^tm1Mem
• Name: huntingtin; targeted mutation 1, Marcy E MacDonald
• MGI ID: MGI:1857180
• Synonyms: Hdh^-, Hdh^ex4/5, Hdh^null, R1Hdh4/5-1d1
• Gene: Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
• Alliance: Htt^tm1Mem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27183
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced exons 4 and 5 of the gene. (J:27183)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	27 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htt Mutation: 179 strains or lines available

References

• Original: J:27183 Duyao MP, et al., Inactivation of the mouse Huntington's disease gene homolog Hdh. Science. 1995 Jul 21;269(5222):407-10
• All: 13 reference(s)