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Hbbtm1Unc
Targeted Allele Detail
Nomenclature
Symbol: Hbbtm1Unc
Name: hemoglobin beta chain complex; targeted mutation 1, University of North Carolina
MGI ID: MGI:1857179
Synonyms: Hbbth2
Gene: Hbb  Location: unknown  Genetic Position: Chr7, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:4932
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 2 of the beta1 gene. No protein for the targeted gene was detected via cellulose electrophoresis of hemoglobin from homozygous mutant mice. (J:4932)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hbb Mutation:  26 strains or lines available
References
Original:  J:4932 Shehee WR, et al., Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3177-81
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory