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Gja1tm1Kdr
Targeted Allele Detail
Nomenclature
Symbol: Gja1tm1Kdr
Name: gap junction protein, alpha 1; targeted mutation 1, Gerald M Kidder
MGI ID: MGI:1857177
Synonyms: Cx43-, Cx43aplha1KO, Cx43 KO
Gene: Gja1  Location: Chr10:56377300-56390419 bp, + strand  Genetic Position: Chr10, 28.64 cM
E16.5 and E18.5 Gja1tm1Kdr/Gja1tm1Kdr skulls are hypomineralized

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:24121
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A promoterless neomycin gene was inserted in-frame into exon 2. (J:24121)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 71 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gja1 Mutation:  34 strains or lines available
References
Original:  J:24121 Reaume AG, et al., Cardiac malformation in neonatal mice lacking connexin43 [see comments]. Science. 1995 Mar 24;267(5205):1831-4
All:  78 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory