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Gja1tm1Kdr
Targeted Allele Detail
Summary
Symbol: Gja1tm1Kdr
Name: gap junction protein, alpha 1; targeted mutation 1, Gerald M Kidder
MGI ID: MGI:1857177
Synonyms: Cx43-, Cx43aplha1KO, Cx43 KO
Gene: Gja1  Location: Chr10:56253297-56266519 bp, + strand  Genetic Position: Chr10, 28.64 cM
Alliance: Gja1tm1Kdr page
E16.5 and E18.5 Gja1tm1Kdr/Gja1tm1Kdr skulls are hypomineralized

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:24121
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A promoterless neomycin gene was inserted in-frame into exon 2. (J:24121)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 98 assay results
3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 29 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Gja1tm1Kdr
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gja1 Mutation:  59 strains or lines available
References
Original:  J:24121 Reaume AG, et al., Cardiac malformation in neonatal mice lacking connexin43 [see comments]. Science. 1995 Mar 24;267(5205):1831-4
All:  101 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory