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Gabrb3tm1Geh
Targeted Allele Detail
Summary
Symbol: Gabrb3tm1Geh
Name: gamma-aminobutyric acid (GABA) A receptor, subunit beta 3; targeted mutation 1, Gregg E Homanics
MGI ID: MGI:1857174
Synonyms: beta3-
Gene: Gabrb3  Location: Chr7:57240266-57478550 bp, + strand  Genetic Position: Chr7, 33.53 cM
Alliance: Gabrb3tm1Geh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39801
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced 2.8 kb of sequence, including exons 1-3. (J:39801)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabrb3 Mutation:  22 strains or lines available
References
Original:  J:39801 Homanics GE, et al., Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4143-8
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory