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Targeted Allele Detail
Symbol: Fn1tm1Hyn
Name: fibronectin 1; targeted mutation 1, Richard Hynes
MGI ID: MGI:1857170
Synonyms: Fn-, FNnull, FN.null
Gene: Fn1  Location: Chr1:71624679-71692359 bp, - strand  Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
Germline Transmission:  Earliest citation of germline transmission: J:16247
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced 0.8 kb of the gene including the translation initiation site and part of the signaling sequence. Plasma concentrations of fibronectin in heterozygotes were one-half those of wild-type littermates. The encoded protein was not detectable in immunoprecipitations from cultures of homozygous mutant E7.5 embryos. (J:16247)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 29 assay results
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Fn1 Mutation:  90 strains or lines available
Original:  J:16247 George EL, et al., Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development. 1993 Dec;119(4):1079-91
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory