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Kdrtm1Jrt
Targeted Allele Detail
Nomenclature
Symbol: Kdrtm1Jrt
Name: kinase insert domain protein receptor; targeted mutation 1, Janet Rossant
MGI ID: MGI:1857168
Synonyms: flk-1-, Flk1-, flk-1/lacZ, Flk1lacZ, Flk1lacZ, Flk1-lacZ neo-in, flk.lacZ, VEGFR-2-, Vegfr2lacZ
Gene: Kdr  Location: Chr5:75932827-75978458 bp, - strand  Genetic Position: Chr5, 40.23 cM
Suppression of of extraretinal vascular outgrowth in ischemic Kdrtm1.1Jamb/Kdrtm1Jrt Tg(CAG-cre/Esr1*)1Egwa/0 retinas

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:26846
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsInsertion of an in-frame lacZ gene and a floxed PGK-neomycin resistance cassette replaced the translated portion of the first coding exon and the proximal part of the next intron, and placed lacZ under the transcriptional control of the endogenous promoter. Neither RT-PCR using total RNA nor Western blot analysis using a carboxy terminal antibody detected gene expression in E8.5 homozygous mutant embryos. (J:26846)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 300 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kdr Mutation:  10 strains or lines available
References
Original:  J:26846 Shalaby F, et al., Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 1995 Jul 6;376(6535):62-6
All:  71 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory