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En2tm1Alj
Targeted Allele Detail
Nomenclature
Symbol: En2tm1Alj
Name: engrailed 2; targeted mutation 1, Alexandra L Joyner
MGI ID: MGI:1857164
Synonyms: En2-, en-2hd
Gene: En2  Location: Chr5:28165696-28173612 bp, + strand  Genetic Position: Chr5, 13.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67524
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 28 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any En2 Mutation:  94 strains or lines available
Notes
Mice heterozygous for En1tm1Gld and homozygous for En2tm1Alj display Phenotypic Similarity to Human Syndrome: Parkinson Disease (J:115270)

References
Original:  J:67524 Joyner AL, et al., Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science. 1991 Mar 8;251(4998):1239-43
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory