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En2tm1Alj
Targeted Allele Detail
Summary
Symbol: En2tm1Alj
Name: engrailed 2; targeted mutation 1, Alexandra L Joyner
MGI ID: MGI:1857164
Synonyms: En2-, en-2hd
Gene: En2  Location: Chr5:28370692-28377164 bp, + strand  Genetic Position: Chr5, 13.94 cM
Alliance: En2tm1Alj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67524
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 1 kb of sequence containing 300 bp of intron and 700 bp of the homeobox exon. (J:67524)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 28 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any En2 Mutation:  104 strains or lines available
References
Original:  J:67524 Joyner AL, et al., Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science. 1991 Mar 8;251(4998):1239-43
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory