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En1tm1Alj
Targeted Allele Detail
Nomenclature
Symbol: En1tm1Alj
Name: engrailed 1; targeted mutation 1, Alexandra L Joyner
MGI ID: MGI:1857163
Synonyms: En-1hd
Gene: En1  Location: Chr1:120602418-120607992 bp, + strand  Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:19212
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin selection cassette replaced 0.85 kb of exon 2, which encodes part of the homeobox domain. (J:19212)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 107 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any En1 Mutation:  8 strains or lines available
References
Original:  J:19212 Wurst W, et al., Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development. 1994 Jul;120(7):2065-75
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory