About   Help   FAQ
Targeted Allele Detail
Symbol: Ednrbtm1Ywa
Name: endothelin receptor type B; targeted mutation 1, Masashi Yanagisawa
MGI ID: MGI:1857161
Synonyms: enrb/enrb
Gene: Ednrb  Location: Chr14:103814625-103844402 bp, - strand  Genetic Position: Chr14, 53.05 cM
Colon crypt proliferation in Ednrbtm1Ywa/Ednrbtm1Ywa mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:22206
Parent Cell Line:  JH1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a 4.2kb segment of the gene, which contained exon 3. Exon 3 encodes the fourth transmembrane helix of the protein. Functional analysis showed that the allele is null. (J:22206)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Ednrb Mutation:  74 strains or lines available
Original:  J:22206 Hosoda K, et al., Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell. 1994 Dec 30;79(7):1267-76
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory