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Edn3tm1Ywa
Targeted Allele Detail
Nomenclature
Symbol: Edn3tm1Ywa
Name: endothelin 3; targeted mutation 1, Masashi Yanagisawa
MGI ID: MGI:1857160
Synonyms: edn3
Gene: Edn3  Location: Chr2:174760619-174784042 bp, + strand  Genetic Position: Chr2, 98.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:22207
Parent Cell Line:  JH1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into the middle of exon 2, deleting the mature Edn3-encoding portion of the exon. No mature Edn3 protein was detected by EIA of kidney, brain, or intestine from homozygous mutant mice. (J:22207)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Edn3 Mutation:  17 strains or lines available
References
Original:  J:22207 Baynash AG, et al., Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell. 1994 Dec 30;79(7):1277-85
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/05/2018
MGI 6.12
The Jackson Laboratory