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Targeted Allele Detail
Symbol: Cd5tm1Cgn
Name: CD5 antigen; targeted mutation 1, University of Cologne
MGI ID: MGI:1857148
Synonyms: CD5-, CD50, CD5T
Gene: Cd5  Location: Chr19:10718107-10739026 bp, - strand  Genetic Position: Chr19, 7.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:19317
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin gene replaced part of exon 7, which encodes the transmembrane domain. An additional frameshift mutation was introduced into exon 3. Flow cytometry analysis on cells derived from thymus, spleen and the peritoneal cavity of homozygous mice confirmed that no detectable protein was expressed from this allele. (J:19317)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd5 Mutation:  24 strains or lines available
Original:  J:19317 Tarakhovsky A, et al., Lymphocyte populations and immune responses in CD5-deficient mice. Eur J Immunol. 1994 Jul;24(7):1678-84
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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