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Targeted Allele Detail
Symbol: Agtr1atm1Unc
Name: angiotensin II receptor, type 1a; targeted mutation 1, University of North Carolina
MGI ID: MGI:1857147
Synonyms: Agt1ar-, Agtr1A-, Agtr1tm1Unc, At1A-, AT1A-KO, AT1aR-, AT1AR KO, AT1-R-
Gene: Agtr1a  Location: Chr13:30336441-30382867 bp, + strand  Genetic Position: Chr13, 13.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:24354
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 0.5kb genomic fragment containing part of the coding sequences of the gene was replaced with a neomycin selection cassette. Binding studies in kidney indicated that no functional protein was detectable in homozygous mice. (J:24354)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Agtr1a Mutation:  15 strains or lines available
Kidneys of these null receptor mice are normal except for some expansion of renin-producing cells (J:45507).
Original:  J:24354 Ito M, et al., Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3521-5
All:  127 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory