About   Help   FAQ
Cd4tm1Mak
Targeted Allele Detail
Summary
Symbol: Cd4tm1Mak
Name: CD4 antigen; targeted mutation 1, Tak Mak
MGI ID: MGI:1857144
Synonyms: CD4-, CD40, CD4 KO
Gene: Cd4  Location: Chr6:124841655-124865184 bp, - strand  Genetic Position: Chr6, 59.17 cM
Alliance: Cd4tm1Mak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68957
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 5. Flow cytometry analysis demonstrated that the protein was absent from the cell surface of thymocytes and lymph node cells in homozygous mice. (J:68957)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Cd4tm1Mak
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Cd4 Mutation:  82 strains or lines available
References
Original:  J:68957 Rahemtulla A, et al., Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature. 1991 Sep 12;353(6340):180-4
All:  244 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory