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Cd4tm1Knw
Targeted Allele Detail
Nomenclature
Symbol: Cd4tm1Knw
Name: CD4 antigen; targeted mutation 1, Barbara B Knowles
MGI ID: MGI:1857143
Synonyms: CD4-, CD4D
Gene: Cd4  Location: Chr6:124864692-124888221 bp, - strand  Genetic Position: Chr6, 59.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48775
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A neomycin resistance gene was inserted into exon 5. (J:48775)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Cd4 Mutation:  46 strains or lines available
References
Original:  J:48775 McCarrick JW 3rd, et al., Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells. Transgenic Res. 1993 Jul;2(4):183-90
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory