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Targeted Allele Detail
Symbol: Bdkrb2tm1Jfh
Name: bradykinin receptor, beta 2; targeted mutation 1, J Fred Hess
MGI ID: MGI:1857135
Synonyms: B2-, B2-KO, B2R-, BdkrB2, Bk2r-, Bk B2R-, rB2 -
Gene: Bdkrb2  Location: Chr12:105563172-105593071 bp, + strand  Genetic Position: Chr12, 55.76 cM
Histological changes in the postischemic kidneys of wild type, Bdkrb2tm1Jfh/Bdkrb2tm1Jfh and MGI:3710159/MGI:3710159 mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:25953
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced the entire coding sequences of the gene. Binding assays on membranes prepared from ileum tissue of homozygous mice confirmed that no functional protein is produced from this allele. (J:25953)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Bdkrb2 Mutation:  15 strains or lines available
Original:  J:25953 Borkowski JA, et al., Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons. J Biol Chem. 1995 Jun 9;270(23):13706-10
All:  73 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.04
The Jackson Laboratory