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Targeted Allele Detail
Symbol: Bcl2tm1Sjk
Name: B cell leukemia/lymphoma 2; targeted mutation 1, Stanley J Korsmeyer
MGI ID: MGI:1857134
Synonyms: Bcl-2-, BclIItm1Sjk
Gene: Bcl2  Location: Chr1:106538178-106714274 bp, - strand  Genetic Position: Chr1, 49.76 cM
Germline Transmission:  Earliest citation of germline transmission: J:15224
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.1 kb genomic fragment containing all of the coding region of exon 3 was replaced with a neomycin selection cassette. The authors state that no full length or truncated protein was detected in vitro or in vivo (data not shown). (J:15224)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 24 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl2 Mutation:  15 strains or lines available
Original:  J:15224 Veis DJ, et al., Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell. 1993 Oct 22;75(2):229-40
All:  35 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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