About   Help   FAQ
B2mtm1Unc
Targeted Allele Detail
Nomenclature
Symbol: B2mtm1Unc
Name: beta-2 microglobulin; targeted mutation 1, University of North Carolina
MGI ID: MGI:1857133
Synonyms: b2mnull, beta2M-, beta2m0, beta2-m-KO, beta2MKO, beta2mnull, beta2mo, beta2mtm1Unc, I0, MHC-I-
Gene: B2m  Location: Chr2:122147686-122153083 bp, + strand  Genetic Position: Chr2, 60.55 cM, cytoband F1-F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65612
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (knock-out)
Mutation:    Insertion
    Insertion of a neomycin-resistance gene into the second exon. (J:65612)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 29 strains available      Cell Lines: 0 lines available
Carrying any B2m Mutation:  45 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:51450)

References
Original:  J:65612 Koller BH, et al., Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8932-5
All:  400 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory