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B2mtm1Unc
Targeted Allele Detail
Summary
Symbol: B2mtm1Unc
Name: beta-2 microglobulin; targeted mutation 1, University of North Carolina
MGI ID: MGI:1857133
Synonyms: b2mnull, beta2M-, beta2m0, beta2-m-KO, beta2MKO, beta2mnull, beta2mo, beta2mtm1Unc, I0, MHC-I-
Gene: B2m  Location: Chr2:121978168-121983563 bp, + strand  Genetic Position: Chr2, 60.55 cM, cytoband F1-F3
Alliance: B2mtm1Unc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65612
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    Insertion of a neomycin-resistance gene into the second exon. (J:65612)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying B2mtm1Unc
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 38 strains available      Cell Lines: 0 lines available
Carrying any B2m Mutation:  122 strains or lines available
References
Original:  J:65612 Koller BH, et al., Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8932-5
All:  543 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory