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Ass1tm1Bay
Targeted Allele Detail
Nomenclature
Symbol: Ass1tm1Bay
Name: argininosuccinate synthetase 1; targeted mutation 1, Baylor College of Medicine
MGI ID: MGI:1857131
Synonyms: Ass-
Gene: Ass1  Location: Chr2:31470207-31520672 bp, + strand  Genetic Position: Chr2, 21.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:18326
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 4 of the gene. Activity assays in liver extracts from homozygous mice demostrated the absence of the functional protein. (J:18326)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ass1 Mutation:  54 strains or lines available
References
Original:  J:18326 Patejunas G, et al., Generation of a mouse model for citrullinemia by targeted disruption of the argininosuccinate synthetase gene. Somat Cell Mol Genet. 1994 Jan;20(1):55-60
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory