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Asgr2tm1Her
Targeted Allele Detail
Nomenclature
Symbol: Asgr2tm1Her
Name: asialoglycoprotein receptor 2; targeted mutation 1, Joachim Herz
MGI ID: MGI:1857130
Synonyms: ASGP-R2-, HL-2 -
Gene: Asgr2  Location: Chr11:70092644-70106187 bp, + strand  Genetic Position: Chr11, 42.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:21380
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 2. Northern blot analysis demonstrated that the transcript was not detectable in liver RNA from homozygous mice. The protein was also not detected in liver membrane protein fractions derived from homozygous mice. (J:21380)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Asgr2 Mutation:  9 strains or lines available
References
Original:  J:21380 Ishibashi S, et al., Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit. J Biol Chem. 1994 Nov 11;269(45):27803-6
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory