About   Help   FAQ
Apoetm1Unc
Targeted Allele Detail
Nomenclature
Symbol: Apoetm1Unc
Name: apolipoprotein E; targeted mutation 1, University of North Carolina
MGI ID: MGI:1857129
Synonyms: AopE(-), apoE-, apoE0, ApoE-KO, APOE KO, Apoetm1Un, EKO, epsilon-, mE-, mEKO
Gene: Apoe  Location: Chr7:19696109-19699188 bp, - strand  Genetic Position: Chr7, 9.94 cM
Morphology of aortic lesions in Apoetm1Unc/Apoetm1Unc and Apoetm1Unc/Apoetm1Unc Ttpatm1Far/Ttpatm1Far mice

Show the 10 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:1050
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsInsertion of a neomycin resistance cassette deleted part of exon 3 and part of intron 3 of the Apoe gene. Plasma from homozygous mutant mice gave no detectable immunoprecipitate by the Ouchterlony double immunodiffusion test using a rabbit antibody to rat APOE. (J:1050)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 34 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 24 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  81 strains or lines available
References
Original:  J:1050 Piedrahita JA, et al., Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4471-5
All:  1436 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/15/2018
MGI 6.12
The Jackson Laboratory