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Alox5tm1Fun
Targeted Allele Detail
Nomenclature
Symbol: Alox5tm1Fun
Name: arachidonate 5-lipoxygenase; targeted mutation 1, Colin Funk
MGI ID: MGI:1857125
Synonyms: 5-LO-, 5LO-, 5-LO KO, 5-LOX-, 5-LOX K/O, 5LX-
Gene: Alox5  Location: Chr6:116410077-116461178 bp, - strand  Genetic Position: Chr6, 53.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:21372
Parent Cell Line:  D3H (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin resistance cassette into exon 6 disrupted the Alox5 gene. RT-PCR studies did not detect transcript in resident peritoneal macrophages of homozygous mutant mice. Western blot analysis of resident peritoneal macrophages of homozygous mutant mice did not detect ALOX5. (J:21372)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Alox5 Mutation:  23 strains or lines available
References
Original:  J:21372 Chen XS, et al., Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature. 1994 Nov 10;372(6502):179-82
All:  92 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory