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Targeted Allele Detail
Symbol: Agtr2tm1Gsb
Name: angiotensin II receptor, type 2; targeted mutation 1, Gregory S Barsh
MGI ID: MGI:1857123
Synonyms: AT2-KO
Gene: Agtr2  Location: ChrX:21350863-21355072 bp, + strand  Genetic Position: ChrX, 16.71 cM
Germline Transmission:  Earliest citation of germline transmission: J:29456
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin cassette was inserted into exon 3, into sequences encoding the region after the first putative transmembrane domain of the receptor. A 209 bp segment of the coding region is also deleted. Northern blot analysis demonstrated that no transcript is produced from this allele in homozygous female or hemizygous male mice. (J:29456)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 55 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agtr2 Mutation:  9 strains or lines available
Original:  J:29456 Hein L, et al., Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature. 1995 Oct 26;377(6551):744-7
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory