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Agttm1Unc
Targeted Allele Detail
Nomenclature
Symbol: Agttm1Unc
Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8); targeted mutation 1, University of North Carolina
MGI ID: MGI:1857121
Synonyms: AGT-
Gene: Agt  Location: Chr8:125283326-125296445 bp, - strand  Genetic Position: Chr8, 72.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:24156
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment within exon 2 that codes for 114 amino acids of the encoded protein was replaced with a neomycin selection cassette. Radioimmunoassay tests confirmed that no protein was detectable in plasma of homozygous mice. (J:24156)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Agt Mutation:  23 strains or lines available
Notes
Human AGT and renin genes can complement the effects of the mouse null mutation (J:39934).
References
Original:  J:24156 Kim HS, et al., Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2735-9
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory