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Adrb1tm1Bkk
Targeted Allele Detail
Nomenclature
Symbol: Adrb1tm1Bkk
Name: adrenergic receptor, beta 1; targeted mutation 1, Brian K Kobilka
MGI ID: MGI:1857120
Synonyms: Adrb1tm1Gsb, beta1-AR-, Beta1-KO
Gene: Adrb1  Location: Chr19:56722372-56724862 bp, + strand  Genetic Position: Chr19, 51.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34659
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1364 bp genomic fragment containing the initiation codon was replaced with a neomycin selection cassette. No protein product was detected on Western blots of heart tissue from homozygous mutant mice. (J:34659)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adrb1 Mutation:  1 strain or line available
References
Original:  J:34659 Rohrer DK, et al., Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects. Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7375-80
All:  44 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory