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Targeted Allele Detail
Symbol: Adra2ctm1Gsb
Name: adrenergic receptor, alpha 2c; targeted mutation 1, Gregory S Barsh
MGI ID: MGI:1857119
Synonyms: alpha2C-, alpha2C-ARKO, alpha2C-KO
Gene: Adra2c  Location: Chr5:35435910-35439107 bp, + strand  Genetic Position: Chr5, 18.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:29109
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin cassette was inserted into the single coding exon. Northern blot analysis and RT-PCR analysis did not detect functional transcript produced from this allele in homozygous mice. (J:29109, J:77486)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adra2c Mutation:  12 strains or lines available
Original:  J:29109 Link RE, et al., Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog. Mol Pharmacol. 1995 Jul;48(1):48-55
All:  43 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory