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Targeted Allele Detail
Symbol: Adra2btm1Gsb
Name: adrenergic receptor, alpha 2b; targeted mutation 1, Gregory S Barsh
MGI ID: MGI:1857118
Synonyms: alpha2B-, alpha2B-KO
Gene: Adra2b  Location: Chr2:127205128-127209141 bp, + strand  Genetic Position: Chr2, 61.95 cM
Dilated right ventricle in Adra2btm1Gsb/Adra2btm1Gsb mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:34819
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into the coding sequences, placing a premature stop codon before the sequences encoding the fifth transmembrane domain. Western blot analysis on kidney membrane extracts confirmed that the protein was not detectable in homozygous mice. (J:34819)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adra2b Mutation:  14 strains or lines available
Original:  J:34819 Link RE, et al., Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c. Science. 1996 Aug 9;273(5276):803-5
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory