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Acetm1Unc
Targeted Allele Detail
Nomenclature
Symbol: Acetm1Unc
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; targeted mutation 1, University of North Carolina
MGI ID: MGI:1857115
Synonyms: ACE-KO, stst
Gene: Ace  Location: Chr11:105967945-105989964 bp, + strand  Genetic Position: Chr11, 68.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:25284
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 14 of the gene. Exon 14 encodes amino acids critical for the normal function of both isoforms of the protein. (J:25284)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ace Mutation:  4 strains or lines available
References
Original:  J:25284 Krege JH, et al., Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature. 1995 May 11;375(6527):146-8
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory