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Ph
Spontaneous Allele Detail
Nomenclature
Symbol: Ph
Name: patch deletion region; patch
MGI ID: MGI:1857106
Synonyms: PdgfrPh
Gene: Ph  Location: Chr5:75315348-75330641 bp  Genetic Position: Chr5, Syntenic
Ph/Ph+

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/Gr
Mutation
description
Allele Type:    Spontaneous
Mutation:    Deletion
  Ph involves 1 genes/genome features (Pdgfra) View all
 
Mutation detailsA deletion region including the Pdgfra gene. Precise breakpoints have not been mapped, but does not extend into the coding sequences of the adjacent Kit gene. However, expression of Kit is altered in these mutants. (J:10920, J:11255, J:23149, J:41383)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 72 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ph Mutation:  1 strain or line available
Notes
Repulsion double heterozygotes of Ph and the allele KitW-ct at the closely linked Kit locus (Ph +/+ KitW-ct) are more anemic than Kit heterozygotes (+ KitW-ct/+ +) alone, have significantly raised leucocyte counts, and are unduly sensitive to whole body X-irradiation, indicating that the Ph locus exerts some control over hematopoiesis (J:7216). Studies of Ph homozygous embryos suggest that Ph protein is required for normal development of non-neuronal neural crest-derived structures (J:1107) and visceral endoderm and mesoderm derivatives (J:1108).
References
Original:  J:99 Gruneberg H, et al., Two closely linked genes in the mouse. Genet Res. 1960;1:69-90
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory