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MipCat-Fr
Spontaneous Allele Detail
Nomenclature
Symbol: MipCat-Fr
Name: major intrinsic protein of eye lens fiber; dominant cataract Fraser
MGI ID: MGI:1857104
Synonyms: Cat60, shrivelled, Svl
Gene: Mip  Location: Chr10:128225838-128231812 bp, + strand  Genetic Position: Chr10, 76.49 cM, cytoband D1
Mutation
origin
Strain of Origin:  A/J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Transposon insertion
 
Mutation details
Inheritance:    Semidominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mip Mutation:  20 strains or lines available
Notes
In chimeric embryos formed between a strain of mice homozygous for MipCat-Fr and the DBA/2 strain, homozygous for the wild-type Mip allele, the lens is histologically, cellularly, and biochemically normal (J:35863). A study of the lens crystallins shows a decrease in the proportion of a-crystallins and an increase in the proportion of a-crystallins (J:6987). At birth, a-crystallin mRNAs are present in nearly normal amounts and functional capacity but are selectively lost by 40 days of age. The effect is more severe in homozygotes than in heterozygotes. The a-crystallin cellular DNA does not differ from normal (J:7668).

References
Original:  J:206638 Fraser FC, et al., 'Shrivelled', a hereditary degeneration of the lens in the house mouse. Genet Res. 1962;3(3):383-387
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory