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Fndc3asys
Transgenic Allele Detail
Nomenclature
Symbol: Fndc3asys
Name: fibronectin type III domain containing 3A; symplastic spermatids
MGI ID: MGI:1857062
Gene: Fndc3a  Location: Chr14:72537946-72710003 bp, - strand  Genetic Position: Chr14, 37.62 cM
Transgene
origin
Strain of Origin:  (FVB/N x C3H)F1
Transgene
description
Transgene Type:    Transgenic
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsApproximately 20 copies of a Rous sarcoma virus long terminal repeat promoter, lacZ mini gene are integrated as a head to tail concatamer at a single site on mouse chromosome 14. There is in addition a deletion of 1.24 Mb of genomic DNA at the transgene insertion site. Fndc3a is contained in the deleted region. Comparative genome analysis of the 1.2 Mb region of chromosome 14 deleted in Fndc3asys mice with human 8p21 and 13q14 suggests that Fndc3a is the only gene mutated in Fndc3asysmice. (J:119576)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fndc3a Mutation:  14 strains or lines available
References
Original:  J:10611 MacGregor GR, et al., Symplastic spermatids (sys): a recessive insertional mutation in mice causing a defect in spermatogenesis. Proc Natl Acad Sci U S A. 1990 Jul;87(13):5016-20
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory