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Spontaneous Allele Detail
Symbol: Muc19sld
Name: mucin 19; sublingual gland differentiation arrest
MGI ID: MGI:1857043
Gene: Muc19  Location: Chr15:91838326-91934555 bp, + strand  Genetic Position: Chr15, 46.14 cM, cytoband E3
Sublingual gland abnormalities in Muc19tm2Culp/Muc19tm2Culp, and Muc19sld/Muc19sld adults

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  NFS/N
Allele Type:    Spontaneous
Mutation:    Insertion
Mutation detailsA spontaneous mutation inserted two CA repeats in intron 53 that results in decreased transcript stability. Additional mutations include: insertion of two GA repeats within intron 18, insertion of two T residues within intron 57 and a putative site within intron 52 of an TA repeat region that was intractable to sequencing. RT-PCR confirmed the absence of transcript expression in the sublingual gland.
Inheritance:    Recessive
Schematic of the spontaneous Muc19sld mutation
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Muc19 Mutation:  18 strains or lines available
In order to be a model for Sjogren syndrome mice must be homozygous for sld and have had a thymectomy at 3 days of age (J:20364)

Original:  J:25317 Kojima A, New mutant: Sublingual gland differentiation arrest in the NFS/N subline. Mouse News Lett. 1988;80:147
All:  16 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory