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Muc19sld
Spontaneous Allele Detail
Nomenclature
Symbol: Muc19sld
Name: mucin 19; sublingual gland differentiation arrest
MGI ID: MGI:1857043
Gene: Muc19  Location: Chr15:91838326-91934555 bp, + strand  Genetic Position: Chr15, 46.14 cM, cytoband E3
Sublingual gland abnormalities in Muc19tm2Culp/Muc19tm2Culp, and Muc19sld/Muc19sld adults

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  NFS/N
Mutation
description
Allele Type:    Spontaneous
Mutation:    Insertion
 
Mutation detailsA spontaneous mutation inserted two CA repeats in intron 53 that results in decreased transcript stability. Additional mutations include: insertion of two GA repeats within intron 18, insertion of two T residues within intron 57 and a putative site within intron 52 of an TA repeat region that was intractable to sequencing. RT-PCR confirmed the absence of transcript expression in the sublingual gland.
Inheritance:    Recessive
Schematic of the spontaneous Muc19sld mutation
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Muc19 Mutation:  2 strains or lines available
Notes
In order to be a model for Sjogren syndrome mice must be homozygous for sld and have had a thymectomy at 3 days of age (J:20364)

References
Original:  J:25317 Kojima A, New mutant: Sublingual gland differentiation arrest in the NFS/N subline. Mouse News Lett. 1988;80:147
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory