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Frem2my
Radiation induced Allele Detail
Nomenclature
Symbol: Frem2my
Name: Fras1 related extracellular matrix protein 2; myelencephalic blebs
MGI ID: MGI:1856964
Synonyms: h, mbl
Gene: Frem2  Location: Chr3:53513939-53657355 bp, - strand  Genetic Position: Chr3, 25.24 cM
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Radiation induced
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 21 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Frem2 Mutation:  7 strains or lines available
Notes
Found among the descendants of irradiated mice (J:14847). Effects are variable, and penetrance is incomplete. This mutant has been the subject of a large number of investigations reviewed by Gr"uneberg (J:30758). The genetics and development were reinvestigated by Carter (J:221, J:13050) who concluded that the effects of this mutation include: embryonic subepidermal blebs leading to abnormalities of the eyes, skin, and hair, and clubbing of the feet; split sternum, pseudencephaly, acrania, renal agenesis, preaxial polydactyly, and syndactyly of the middle digits; and probably also hydronephrosis, ectopia viscerum, and midcerebral lesions.

References
Original:  J:14847 Little CC, et al., The occurrence of two heritable types of abnormality among descendants of X-rayed mice. Am J Roentgenol. 1923;10:975-989
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory