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Foxe3dyl
Spontaneous Allele Detail
Nomenclature
Symbol: Foxe3dyl
Name: forkhead box E3; dysgenetic lens
MGI ID: MGI:1856851
Synonyms: dyl
Gene: Foxe3  Location: Chr4:114925147-114926013 bp, - strand  Genetic Position: Chr4, 52.73 cM, cytoband C7
Mutation
origin
Strain of Origin:  BALB/cLiA
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsTwo missense mutations in the sequences encoding the forkhead domain were shown to cosegregate with the dyl phenotype: two C to T transitions at positions 277 and 293 that change codons 93 and 98 from phenylalanine to leucine and serine respectively. These mutations are in a region of the protein thought to be critical for DNA binding. (J:59880)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 11 assay results
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxe3 Mutation:  2 strains or lines available
References
Original:  J:6131 Sanyal S, et al., Dysgenetic lens (dyl)--a new gene in the mouse. Invest Ophthalmol Vis Sci. 1979 Jun;18(6):642-5
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory