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Wnt9bclf1
Spontaneous Allele Detail
Nomenclature
Symbol: Wnt9bclf1
Name: wingless-type MMTV integration site family, member 9B; cleft lip 1
MGI ID: MGI:1856821
Gene: Wnt9b  Location: Chr11:103618190-103640647 bp, - strand  Genetic Position: Chr11, 67.47 cM
Normal and Wnt9bclf1/Wnt9bclf1 mouse embryo

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  A/WySn
Mutation
description
Allele Type:    Spontaneous
Mutation:    Insertion
 
Mutation detailsThis mutation is a novel insertion of an IAP transposon 3' from the gene. In addition, a standard genetic test of allelism between clf1 and a Wnt9b targeted mutation demonstrated noncomplementation, showing clf1 is an allele of Wnt9b. (J:96061, J:117594)
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Wnt9b Mutation:  18 strains or lines available
Notes
Unequal duplicate epistasis - the normal allele at clf1 is a dominant suppressor of the recessive phenotype at clf2, and the normal allele at clf2 is a semidominant suppressor of the recessive phenotype at the clf1 locus.
References
Original:  J:22596 Juriloff DM, Major genes that cause cleft lip in mice: progress in the construction of a congenic strain and in linkage mapping. J Craniofac Genet Dev Biol Suppl. 1986;2:55-66
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory