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Spontaneous Allele Detail
Symbol: Foxc1ch
Name: forkhead box C1; congenital hydrocephalus
MGI ID: MGI:1856705
Synonyms: ch, mf1ch
Gene: Foxc1  Location: Chr13:31990629-31994618 bp, + strand  Genetic Position: Chr13, 13.52 cM

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  CBA x STOCK Tyrc f
Allele Type:    Spontaneous
Mutation:    Single point mutation
Mutation detailsA transition point mutation at coding nucleotide 367 altered a C to a T in the coding region. This results in a stop codon in place of glutamine codon 123 (p.Q123*) in the sequences encoding the third helix of the WH domain. The authors predict that a truncated protein would be generated lacking DNA binding activity. (J:48079)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 75 assay results
In Structures Affected by this Mutation: 84 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxc1 Mutation:  13 strains or lines available
Original:  J:75733 Gruneberg H, Congenital hydrocephalus in the mouse, a case of spurious pleiotropism. J Genet. 1943;45(1):1-21
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory