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Chemically induced Allele Detail
Symbol: Flt4Chy
Name: FMS-like tyrosine kinase 4; chylous ascites
MGI ID: MGI:1856694
Synonyms: Chy, Vegfr3TKmut
Gene: Flt4  Location: Chr11:49609263-49652739 bp, + strand  Genetic Position: Chr11, 29.69 cM, cytoband A5-B1
Defective lymphatic vessels in the Flt4Chy/Flt4+ mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  C3H
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsThe mutation resulting in the Chy phenotype is an A-to-T mutation at position 3157 resulting in an isoleucine to phenylalanine substitution at position 1053 in the tyrosine kinase domain. This mutation is located in a highly conserved catalytic domain of the receptor, in close proximity to the VEGFR-3 mutations in human primary lymphedema. In addition, the Chy mutation was shown to be allelic to an existing targeted mutation in this gene. (J:72387)
Inheritance:    Semidominant
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Flt4 Mutation:  6 strains or lines available
Original:  J:13981 Lyon MF, et al., Chylous ascites (Chy). Mouse News Lett. 1984;71:26
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory