Col4a1^Bru
Chemically induced Allele Detail

Summary

• Symbol: Col4a1^Bru
• Name: collagen, type IV, alpha 1; bruised
• MGI ID: MGI:1856689
• Gene: Col4a1 Location: Chr8:11248423-11362826 bp, - strand Genetic Position: Chr8, 5.53 cM
• Alliance: Col4a1^Bru page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis resulted in an G>T point mutation in exon 26 resulting in the substitution of glycine with tryptophan at position 627 of the encoded peptide (p.G627W). This is predicted to cause severe detrimental effects on collagen triple helix formation and stability. (J:102749)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Col4a1 Mutation: 77 strains or lines available

Notes

The bruised mutation was found among offspring of a male treated with ethylnitrosourea (J:13980).

References

• Original: J:13980 Lyon MF, et al., Bruised (Bru). Mouse News Lett. 1984;71:26
• All: 2 reference(s)